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HOST RESISTANCE TO TRICHINELLA SPIRALIS INFECTION IN RATS EXPOSED TO 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)
Citation:
Luebke, R., C. Copeland, AND D. Andrews. HOST RESISTANCE TO TRICHINELLA SPIRALIS INFECTION IN RATS EXPOSED TO 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/211.
Description:
We have previously shown decreased resistance to Trichinella spiralis (Ts) infection, and reduced parasite antigen-specific responses in mice exposed to TCDD before infection. he present study was done to characterize the effects of preinfection administration of 1, 10, or 30 ug TCDD/kg on host resistance of F344 female rats to Ts infection and to examine parasite antigen-specific responses in the spleen and mesenteric lymph nodes of infected animals. CDD exposure did not affect adult parasite elimination from the small intestine or numbers of encysted larvae In the muscle, although parasite production of larvae was elevated in the highest dose group compared to controls. roliferative responses of lymphocytes cultured with parasite antigen were actually enhanced in groups of rats exposed to 30 ug TCDD/kg. hese results, which are in marked contrast to the effects obtained In B6C3F1 mice, demonstrate a clear species difference in the effects of TCDD on immune function in rodents and underscore the need to determine which type of response most closely reflects the potential outcome of human exposure to TCDD.