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RAT FLASH EVOKED POTENTIAL PEAK N160 AMPLITUDE: MODULATION BY RELATIVE FLASH INTENSITY
Citation:
Herr, D., W. Boyes, AND R. Dyer. RAT FLASH EVOKED POTENTIAL PEAK N160 AMPLITUDE: MODULATION BY RELATIVE FLASH INTENSITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/050 (NTIS PB91191577).
Description:
The flash evoked potential (FEP) of rats has a large negative (N160) approximately 160 msec following stimulation. his peak has been reported to be modulated by the subject's state of behavioral arousal and influenced by several test parameters. hese experiments bind the influences of repeated testing, the number of stimuli/session, interaction of ambient illumination and flash in- tensity and the effect of pupillary dilation on the development and amplitude of peak Nl60. he amplitude of peak N160 increased with daily testing; and reached an asymptotic amplitude by about day 10. his amplitude was affected by the intensity of the flash stimulus relative to the ambient illumination (RFI), and appeared to reach a "ceiling" amplitude at greater than 5o dB RFI. he number of stimuli/session and dilation of the subject's pupils did not have a large influence on the growth or asymptotic level of peak N160 amplitude. he data are consistent with the hypothesis that the growth of peak N160 may represent a sensitization-like phenomenon.