You are here:
LEARNING AND MEMORY DEFICITS IN RATS FOLLOWING EXPOSURE TO 3,3'-IMINODIPROPIONITRILE
Citation:
Peele, D., S. Allison, AND K. Crofton. LEARNING AND MEMORY DEFICITS IN RATS FOLLOWING EXPOSURE TO 3,3'-IMINODIPROPIONITRILE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/279.
Description:
The effects on learning and memory produced by B,B' iminodipropionitrile (IDPN) were examined in rats 4 weeks after dosing. DPN (600 mg/kg) prevented acquisition of a olfactory discrimination task and disrupted performance of passive avoidance conditioning in separate groups of animals. he disruptive effects on passive avoidance conditioning were dosage dependent. ats from both control and treated groups were then tested using a standard hot-plate test. he results suggest that treatment with IDPN did not produce the observed effects on learning and memory by altering sensitivity to painful, external stimuli. n summary, administration of IDPN is capable of producing profound and long lasting disruption of learning and memory in rats.