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CARCINOMA OF THE EXOCRINE PANCREAS IN MEDAKA
Citation:
Hawkins, W., J. Fournie, M. Battalora, AND W. Walker. CARCINOMA OF THE EXOCRINE PANCREAS IN MEDAKA. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/341 (NTIS PB92129782).
Description:
Eight cases of acinar cell carcinoma of the exocrine pancreas were diagnosed in Japanese medaka (Oryzias latipes) from a pool of approximately 10,000 specimens used in a variety of carcinogenesis bioassays. hree cases occurred in specimens from control groups and one case in a specimen exposed to benzo(e)pyrene (BeP), a noncarcinogenic isomer of benzo(a)pyrene (BaP). our cases occurred in specimens exposed to known carcinogens including two cases in specimens exposed to 7,12-dmethylbenz(a)anthracene (DMBA), one in a medaka exposed to benzo(a)pyrene, and one in a specimen exposed to methylazoxymethanol acetate (MAM-Ac). ancreatic carcinoma was probably the cause of death in five cases. he neoplasms appeared to originate in the mesentery near the abdominal surface of the liver.
