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SUBACUTE AND SUBCHRONIC ORAL TOXICITY OF P-CHLOROTOLUENE IN THE RAT
Citation:
Terrill, J., M. Robinson, G. Wolfe, AND L. Billups. SUBACUTE AND SUBCHRONIC ORAL TOXICITY OF P-CHLOROTOLUENE IN THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/537.
Description:
P-Chlorotoluene was administered by gavage for 14 and 90 days to male and female Sprague-Dawley-derived rats at dose levels of 200, 600 and 1800 mg/kg/day and 50, 200 and 800 mg/kg/day, respectively. In the 14-day study 8 of 10 animals of each sex in the high-dose group died due to treatment. ther treatment-related signs for these animals included an adverse effect upon body weight, and clinical signs, of salivatIon, tremors and prostration. n the 200 and 600 mg/kg/day groups there were no apparent treatment-related effects. n the 90-day study, 4 of 10 males and 2 of 10 females in the high-dose group died due to treatment. ther signs for this treatment group included an adverse effect upon body weight, and clinical signs of languid behavior, prostration, tremors, sensitive to touch, epistaxis and espiratory distress. ncreases in alkaline Phosphatase and creatinine (males only), and increases in adrenal (absolute and relative, females), kidney (relative, both sexes) and liver (relatIve, both sexes) weights were also noted. Histopathology findings of centrilobular hepatocellular hypertrophy, adrenal cortical hyperplasia and exacerbation of chronic progressive nephropathy confirmed the clinical laboratory and organ weight results as being treatment related for the animals receiving 800 mg/kg/day for 90 days. nimals receiving 50 or 200 mg/kg/day (90 days) did not exhibit treatment-related findings.