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EFFECTS OF AMMONIUM NITRATE AEROSOL EXPOSURE ON LUNG STRUCTURE OF NORMAL AND ELASTASE-IMPAIRED RATS AND GUINEA PIGS
Citation:
Busch, R. AND e. al. EFFECTS OF AMMONIUM NITRATE AEROSOL EXPOSURE ON LUNG STRUCTURE OF NORMAL AND ELASTASE-IMPAIRED RATS AND GUINEA PIGS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-86/550 (NTIS PB91117630).
Description:
Groups of rats and guinea pigs with normal lungs and others with elastase-induced emphysema were exposed to aerosols of 0.60 MMAD at 1 mg/m3 for 6 hr/day, 5 days/wk for 4wk. orphologic and morphometeric studies were performed on lungs perfused with cacodylate-buffered 2% glutaraldehyde under 20 cm H2O pressure at necropsy. he tissues were studied for pathologic change by light microscopic methods, including changes in mean alveolar chord length, using scanning electron techniques. lastase produced emphysema to a quantifiable by all criteria studied; however, it apparently obscured the effects of nitrate inhalation. he NH4NO3 exposures (compared to air alone) tended to increase values for pulmonary parameters in normal animals of both species and to decrease them in elastase-treated animals. he increased values for lung volume in rats, percent area affected in elastase-treated rats, and chord length beta in normal animals of both species. he responses to NH4NO3 were slight (p < 0.10) and were not by any detectable changes in alveolar structure. herefore, the effects of NH4NO3, at this level and duration, are regarded as biologically insignificant for rats and guinea pigs.
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EFFECTS OF AMMONIUM NITRATE AEROSOL EXPOSURE ON LUNG STRUCTURE OF NORMAL AND ELASTASE-IMPAIRED RATS AND GUINEA PIGS