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MATHEMATICAL MODEL FOR AEROSOL DEPOSITION IN THE RESPIRATORY TRACT OF THE GUINEA PIG
Citation:
Martonen, T. AND Y. Yang. MATHEMATICAL MODEL FOR AEROSOL DEPOSITION IN THE RESPIRATORY TRACT OF THE GUINEA PIG. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/325.
Description:
Laboratory animals are used as surrogates in inhalation exposure studies for: 1) risk assessments of air pollutants; and, (2) evaluations of pharmacologic drugs. erein, a mathematical model is presented which identifies factors affecting the regional distribution of inhaled aerosols within the complete respiratory system of the guinea pig. he model couples empirical and deterministic techniques. original empirical formula is presented to describe particle losses in airways of the head and throat. egarding the lung, its structure is defined using the asymmetric morphology of Schreider and Hutchens (198)) and deposition is calculated in a deterministic manner using the protocol of Martonen et al. (1992a,b). esults of our deposition model are compared separately with the theory of Schreider and Hutchens (1979) aid the experimental data of Raabe et al. (1988). rincipal contradictions within the morphological and computational investigations of Schreider and Hutchens (1979, 1980) are disclosed and discussed. esults of the deposition model presented herein are in qualitative agreement with t e laboratory data of Raabe et al. (1988). uantitative differences in deposition values may be attributable to different strains of guinea pig being used in the respective morphological and deposition studies.