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EFFECTS OF SELECTED WATER TOXICANTS ON THE IN VITRO ACTIVITY OF FISH CARBONIC ANHYDRASE
Citation:
Christensen, G. AND J. Tucker. EFFECTS OF SELECTED WATER TOXICANTS ON THE IN VITRO ACTIVITY OF FISH CARBONIC ANHYDRASE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-76/010 (NTIS PB265284).
Description:
Carbonic anhydrase (CA, carbonate hydro-lyase EC 4.2.1.1) from lysed red blood cells of the channel catfish (Ictalurus punctatus) was studied to determine physico-chemical kinetic properties and relative sensitivity to 56 chemicals of significance in water quality research. In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds. Dose-response curves were qualitatively similar in most cases.