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PREDICTORS OF INDIVIDUAL DIFFERENCES IN ACUTE RESPONSE TO OZONE EXPOSURE
Citation:
McDonnell, W., K. Muller, P.A. Bromberg, AND C. Shy. PREDICTORS OF INDIVIDUAL DIFFERENCES IN ACUTE RESPONSE TO OZONE EXPOSURE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/358 (NTIS PB93228849).
Description:
The purposes of this study were to identify personal characteristics which predict individual differences in acute response to ozone exposure and to develop a predictive model for decrements in FEV1 as a function of ozone concentration and individual predictors. esponse and predictor data were collected on 290 white male volunteers ages 18-32 yrs. who were each exposed to one of six concentrations of ozone.between 0.0 and 0.40 part per million. he sample was divided into an exploratory sample of 96 and a confirmatory sample of 194 individuals. xploratory analysis indicated that a logistic model fit the data adequately, and that age and several other variables explained a significant proportion of the variance in response to ozone. n the confirmatory sample, only age and ozone concentration were predictors of FEV 1 decrement.. For the combined sample ozone alone explained 31 % of the variance with age accounting for an additional 4%. he model predicted a decreasing response with increasing age for all ozone concentrations. or exposure to 0.40 ppm, the model predicts decrements in FEV 1 of 1.07 and 0.47 for 18 and 30 year old individuals, respectively. e concluded that for white males a logistic function adequately modelled response as a function of ozone concentration, and that age was a significant predictor of response with older individuals being less responsive to ozone.