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MIREX INDUCES ORNITHINE DECARBOXYLASE ACTIVITY IN FEMALE RAT LIVER
Citation:
Mitra, A., I. Richards, R. Conolly, A. Kulkarni, AND K. Kitchin. MIREX INDUCES ORNITHINE DECARBOXYLASE ACTIVITY IN FEMALE RAT LIVER. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/428.
Description:
Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine synthesis, was significantly induced in female rat liver following oral administration of the pesticide, mirex. fter dual oral exposure (120 mg/kg; 21 and 4 hrs prior to sacrifice) induction of ODC activity in rat liver cytosol was 70-fold as compared to controls. ingle oral dose of mirex (180 mg/kg) induced hepatic ODC activity 55-fold over controls. he time-course study indicated that maximal Induction of ODC actIvity after a single oral dose of mirex was at 36 hours post-dosing. Though the exact mechanism is still unclear, it appears that sex could be a pre-disposing factor in the induction of ODC activity in rat liver. irex is an unusually strong and long lasting Inducer of rat hepatic ODC activity.