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PERMEATION OF MOUSE SKIN AND SILICONE RUBBER MEMBRANES BY PHENOLS: RELATIONSHIP TO IN VITRO PARTITIONING
Citation:
Huq, A., N. Duraiswamy, C. Flynn, N. Ho, W. Jetzer, AND L. Condie, Jr. PERMEATION OF MOUSE SKIN AND SILICONE RUBBER MEMBRANES BY PHENOLS: RELATIONSHIP TO IN VITRO PARTITIONING. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-86/552.
Description:
Cutaneous permeability coefficients of a set of pollutants chosen to span a wide range or polarity; namely N-nitrosodimethylamine, benzidine, benzene, toluene, carbon tetrachloride, hexachlorobenzene and hexachlorobiphenyl; were assessed using closed, water-jacketed diffusion cell designed to prevent evaporative loss of volatile permeants during permeation experiments. nitially the permeabilities of the compounds increased as partition coefficients increased, but they abated abruptly for the hydrophobic, polychlorinated compounds here molecular weights are large. t was apparent from differences between their rates of uptake into the skin and their rates of permeation through it that the skin essentially acts as a reservoir for hexachlorobenzene (log K octanol/water 4.13) and hexachlorobiphenyl (logK octanol/water = 6). o assess the quantity of a particular pollutant which might pass through the skin while person is bathing, swimming, or otherwise in contact with water for extended periods, baseline permeability data have to be gathered either for the compound in question or for a broad enough spectrum of compounds to allow the permeability of the one in question to be inferred. he present study is intended to partially fulfill these needs as it elaborates the skin permeabilities of seven recognized pollutants. hese were selected for their wide range in polarity; therefore, the study also puts the skin's permeability behavior into a chemical structure-permeability framework.