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AIRWAY STRUCTURE IN THE LONG EVANS RAT LUNG
Citation:
Menache, M., A. Patra, AND F. Miller. AIRWAY STRUCTURE IN THE LONG EVANS RAT LUNG. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/311.
Description:
To determine the degree of inter-animal variability among laboratory animals of the same strain and size, lengths and diameters of the same 200 airways were measured in solid casts in each of 10 male Long Evans rats. ntra-animal variability was substantially greater than interanimal variability for airway lengths and diameters. ntra-animal variability was reduced when the airways were grouped so that airway generations were adjusted for lobar position. he study results suggest that detailed measurements of the conducting airways in a small number of casts with summarization techniques that retain lobar information will provide a less variable estimate of lung geometry than a smaller number of measurements made in several casts.