You are here:
INTERDISCIPLINARY APPROACH TO ASSESSING THE HEALTH RISK OF AIR TOXIC CHEMICALS: AN OVERVIEW
Citation:
Grose, E., M. Selgrade, P. Bushnell, J. Simmons, J. Allen, J. McGee, F. Haughman, AND J. Graham. INTERDISCIPLINARY APPROACH TO ASSESSING THE HEALTH RISK OF AIR TOXIC CHEMICALS: AN OVERVIEW. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/347.
Description:
To assist the regulatory branch of the Environmental Protection Agency in addressing the risk assessment of air toxics, the Health Effects Research Laboratory initiated a comprehensive inhalation toxicology program to provide key health effects data missing from the current data base. riority ranking of chemicals based on the potential for substantial human exposure and the need for health effects data was developed to identify candidate chemicals for toxicological research. he major goal of the program is to evaluate the concentration-response from acute, intermittent and subchronic inhalation exposures to developmental, genetic, hepatic, immunologic, neurologic, pulmonary and reproductive toxicity. Although the main emphasis is on inhalation as the primary route of exposure, some of the laboratories will compare inhalation to other routes, such as oral, to better understand the influence of route of exposure an hence the potential applicability of existing health data. cute and intermittent exposures will be done for all compounds. pon evaluation of the acute results, a decision will be made as to whether subchronic studies are needed. ndpoints that show unusual sensitivity may be investigated in greater detail. he total length of exposure will vary from 1 to 21 days. he daily length of exposure will range from 1 to 8 hr. f adverse effects are observed at ambient levels, the time to recovery after exposure will be investigated.