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CHRONIC EXPOSURE TO OZONE CAUSES RESTRICTIVE LUNG DISEASE
Citation:
Grose, E., D. Costa, G. Hatch, R. Jaskot, AND M. Stevens. CHRONIC EXPOSURE TO OZONE CAUSES RESTRICTIVE LUNG DISEASE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-89/102 (NTIS PB89224554).
Description:
A chronic study to determine the progression and or/reversibility of ozone-induced lung disease was conducted. ale rats were exposed to a diurnal pattern of ozone (O3) for 1 wk, 3 wk, 3 mo, 12 mo, or 18 mo. he occurrence of chronic lung disease was determined by structural and functional endpoints. tructurally, a biphasic response was observed with (a) an initial acute inflammatory response after 1 wk of exposure, (b) a reduced acute response after 3 wk of exposure, and (c) an epithelial and interstitial response again observed after 3 mo which persisted or increased in intensity up to l8 mo of exposure. unctional studies showed a persistence of decreased total lung capacity and residual volumes at 3, 12, and 18 mo of exposure, a response indicative of restrictive lung disease. iochemical changes in antioxidant metabolism were also observed after 12 and 18 mo of exposure. ost significant changes were resolved after the clean air recovery period. his study has shown that chronic exposure to O3 causes restrictive lung disease as characterized by the development of focal interstitial fibrosis.