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RAT AND HUMAN VISUAL-EVOKED POTENTIALS RECORDED UNDER COMPARABLE CONDITIONS: A PRELIMINARY ANALYSIS TO ADDRESS THE ISSUE OF PREDICTING HUMAN NEUROTOXIC EFFECTS
Citation:
Boyes, W., K. Hudnell, AND D. Otto. RAT AND HUMAN VISUAL-EVOKED POTENTIALS RECORDED UNDER COMPARABLE CONDITIONS: A PRELIMINARY ANALYSIS TO ADDRESS THE ISSUE OF PREDICTING HUMAN NEUROTOXIC EFFECTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/158.
Description:
A search was undertaken for contributions of sustained and transient visual elements to the rat visual-evoked potential (VEP) using procedures similar to those used in humans (Hudnell et al., in preparation). voked potentials were recorded following either pattern-reversal or pattern-onset stimulation over a range of spatial frequencies, and following adaptation to a stationary grating of the same spatial frequency as the test stimulus. he initial VEP component, a positive peak labeled p1, was early in latency, larger at lower spatial frequencies, larger following pattern-reversal than pattern-onset stimulation, and not reduced in amplitude by adaptation to a stationary grating. hese properties suggest that P1 reflects the activity of a transient, motion-perception visual subsystem. ubsequent in latency to P1 was a negative peak labeled N2 which was largest at intermediate spatial frequencies, larger following pattern-onset than pattern-reversal stimulation, and reduced in amplitude by adaptation to a stationary grating. hese properties suggest that N2 reflects the activity of a pattern-perceptionvisual subsystem. his initial positive/negative complex in rats resembled the properties of a similar complex found in humans (Hudnell et al.,), which indicates that similar processes operate in the two species.