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AUTONOMIC AND BEHAVIORAL THERMOREGULATION IN THE GOLDEN HAMSTER DURING SUBCHRONIC ADMINISTRATION OF CLORGYLINE
Citation:
Gordon, C. AND W. Duncan, Jr. AUTONOMIC AND BEHAVIORAL THERMOREGULATION IN THE GOLDEN HAMSTER DURING SUBCHRONIC ADMINISTRATION OF CLORGYLINE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/530 (NTIS PB95148920).
Description:
Chronic administration of clorgyline, a type-A monoamine oxidase inhibitor, leads to a decrease in peritoneal (i.e., core) temperature of golden hamsters. o better understand the mechanisms of clorgyline's thermoregulatory effects, autonomic and behavioral thermoregulatory effectors were measured in Syrian hamsters following chronic infusion of clorgyline via minipump (2 mg/kg/day). etabolic rate, evaporative water loss, motor activity, and core temperature were measured after 60 min of exposure to ambient temperatures (Ta) of 5, 20, 30, and 35 degrees C. Behavioral thermoregulatory responses were assessed by measuring selected Ta and motor activity of the same animals in a temperature gradient over the course of 23 hr. etabolic rate and motor activity were significantly elevated in clorgyline-treated hamsters exposed to a Ta of 5 ')C. here were no ffects of clorgyline on evaporative water loss. n the temperature gradient the mean selected Ta of clorgyline-treated hamsters was nearly equal to that of the saline-treated hamsters, 30.7 and