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INDUCTION, ACCUMULATION, AND PERSISTENCE OF SISTER CHROMATID EXCHANGES IN WOMEN WITH BREAST CANCER RECEIVING CYCLOPHOSPHAMIDE, ANDRIAMYCIN, AND 5-FLUOROACIL CHEMOTHERAPY
Citation:
Tucker, J., A. Wyrobek, L. Ashworth, M. Christensen, G. Burton, A. Carrano, AND R. Everson. INDUCTION, ACCUMULATION, AND PERSISTENCE OF SISTER CHROMATID EXCHANGES IN WOMEN WITH BREAST CANCER RECEIVING CYCLOPHOSPHAMIDE, ANDRIAMYCIN, AND 5-FLUOROACIL CHEMOTHERAPY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/240.
Description:
The induction, stimulation, and persistence of sister chromatid exchanges (SCE's) and high SCE frequency cells (HFC's) was measured in peripheral lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted of i.v. infusion of cyclophosphamide, Adriamycin, and 5-fluorouracil, administered on day 1 of each of approximately six 21-day cycles. his treatment resulted in a highly significant of SCE's (1.8-fold, p < 0.0001) and HFC's (5- fold, p < 0.0001) measured in samples obtained 1 week after the first therapy. ccumulation of lesions leading to SCE's was measured by comparing samples surrounding the first and last rounds of therapy and was significant for both SCE's and HFC's in most comparisons. ersistence of lesions leading to SCE's was evaluated at multiple times until 9 months after completion of therapy, and both SCE's and HFC's remained significantly elevated throughout this time. ifferences between donors were observed throughout the study, although they were not always consistent with time. ur results also indicate that the SCE frequency declines rapidly within a few weeks after treatment but that residual damage remains up to nine months after the end of chemotherapy.