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FEMALE REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY: OVERVIEW AND CURRENT APPROACHES
Citation:
Kamrin, M., E. Carney, K. Chou, A. Cummings, L. Dostal, C. Harris, J. Henck, AND e. al. FEMALE REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY: OVERVIEW AND CURRENT APPROACHES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/537.
Description:
Current approaches in Reproductive Toxicology encompass a broad spectrum. This review article summarizes several of these approaches, based on presentations at the Symposium on Reproductive ToxicologY in Michigan. here are multiple targets for toxicological injury in the developing embryo and adult organism. ffects of chemicals during pregnancy may differ from those in the non-pregnant organism. he placenta is an organ of interest for pursuing toxicological studies. hole embryo culture is another approach to evaluating toxic effects. eries of protocols has been used to evaluate the sites, stages, and mechanisms in which xenobiotics impact early pregnancy. tudy of gap-junctions is focused on late pregnancy, uterine contractility, and toxic effects thereon. ostnatallY, lactation provides a period of vulnerability to the transfer of xenobiotics to suckling offspring.