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CHEMICAL INDUCTION OF TUMORS IN OYSTERS BY A MIXTURE OF AROMATIC AND CHLORINATED HYDROCARBONS, AMINES, AND METALS
Citation:
Gardner, G.R., R. Pruell, AND A. Malcolm. CHEMICAL INDUCTION OF TUMORS IN OYSTERS BY A MIXTURE OF AROMATIC AND CHLORINATED HYDROCARBONS, AMINES, AND METALS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/310 (NTIS PB93229326).
Description:
Tumors were induced in eastern oysters (Crassotrea virginica) by a mixture f aromatic hydrocarbons, an aromatic amine, polychlori-nated biphenyls, chlorinated hydrocarbons, a nitrosoamine and heavy metals. idney and nteric tumors developed in oysters following exposure to a mixture containing 3,4-benzopyrene, 1,2-benzanthracene, 2-aminofluorene. nitrosodiethylamine, technical chlordane, Aroclors 1242 and 1254. p,p-DDE, cadmium (CdCl2), chromium (K2CrO4) and lead (Pb(NO3)2). he chemical concentrations added to a reference sediment from Long Island Sound were 1 x and 10 x the measured level in sediment from Black Rock Harbor (BRH). ridgeport. onnecticut (normalized for total organic carbon and acid volatile sulfide content for organic and inorganic compounds, respectively). 2-Aminoflourene and N-nitrosodiethyline, not measured in BRH sediment, were both added at 0-6 and 6-0 ug/g dry sediment. % prevalence of low-grade renal and gastrointestinal tumors developed after 30 days in oysters fed water-column suspended sediment particulate spiked with the mixture of chemicals. isease progression was most advanced in enteric adenomas. oth types are comparable to those produced after 30 days in the same organs by chemically contaminated Black Rock Harbor sediment. he action of chemical pollutants reported here represents initial findings in a series of studies designed to test sediment contaminants as causal factors for tumors in oysters.