You are here:
ROLE OF OXIDANTS IN INFLUENZA-INDUCED AIRWAY HYPERREACTIVITY IN RATS
Citation:
Tepper, J., J. Lehmann, J. Hoidal, D. Costa, G. Burleson, AND T. Kennedy. ROLE OF OXIDANTS IN INFLUENZA-INDUCED AIRWAY HYPERREACTIVITY IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-91/204.
Description:
Airway hyperreactivity (AHR) to intravenous acetylcholine has been demonstrated 3d after F-344 rats were intranasally instilled with a rat-adapted influenza virus (ARRD, A657:1990). -acetyl cysteine (NAC), an oxidant scavenger, was able to lock AHR if orally administered (1% in tap water) for 2d prior to virus infection and continued for 3d until AHR was examined. o evaluate if these oxygen radicals derived from altered adenosine metabolism were responsible for AHR, oxypurinol (OXY) was administered (50 mg/kg, i.p.) for 4d prior to virus infection and AHR challenge. irus increased xanthine oxidase (XO) activity and OXY inhibited this effect, but AHR was not blocked. owever, virus-infected OXY-pretreated animals had less protein in the bronchoalveolar lavage suggesting that OXY had reduced a portion of the virus-induced lung damage. xperiments are currently in progress to see if oxidative damage from leukocytes, rather than altered adenosine metabolism, contribute to AHR.