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ANALYSIS OF THE DISTRIBUTION AND DOSE RESPONSE OF CHROMOSOME ABERRATIONS IN HUMAN LYMPHOCYTES AFTER IN VITRO EXPOSURE TO (137) CESIUM GAMMA RADIATION
Citation:
Doggett, N. AND W. McKenzie. ANALYSIS OF THE DISTRIBUTION AND DOSE RESPONSE OF CHROMOSOME ABERRATIONS IN HUMAN LYMPHOCYTES AFTER IN VITRO EXPOSURE TO (137) CESIUM GAMMA RADIATION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/287.
Description:
The chromosome aberration yield for human lymphocytes exposed in vitro to various doses of (137) Cesium has been studied. Dicentric, total acentric, and excess acentric data were seen to follow a Poisson distribution. Calculated total hits demonstrated over-dispersion which could possibly be accounted for by a greater occurrence of single-hit phenomena being repaired than two-hit exchange processes. The resulting distribution generally contained an under-representation of cells with odd numbers of hits and an over-representation of zero- and even-hit classes as compared with Poisson predicted values. A possible use of scoring 'normal' cells for purposes of biological dosimetry is presented.