You are here:
CYTOGENETIC EFFECTS OF PHOSPHINE INHALATION BY RODENTS
Citation:
Kligerman, A., M. Bryant, C. Doerr, G. Erexson, P. Kwanyuen, AND J. McGee. CYTOGENETIC EFFECTS OF PHOSPHINE INHALATION BY RODENTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/046.
Description:
Phosphine (PH3) is a highly toxic grain fumigant that can be produced from the reaction of metal phosphides with water. o determine the in vivo cytogenetic effects of inhalation of PH3, male CD-1 mice were exposed to either 0, 5, 10, or 15 ppm target concentrations of PH3 for 6 h. Twenty h after the termination of exposure, the spleens of the mice were removed, macerated, and the splenocytes cultured for analyses of sister chromatid exchanges, chromosome aberrations, and micronuclei in cytochalasin B-induced binucleated cells. n addition, bone marrow smears were made for the analysis of micronuclei in polychromatic erythrocytes. oincrease in any of the cytogenetic endpoints was found at any f the concentrations examined. he only statistically significant response was a concentration-related slowing of the cell cycle in the splenocytes.