You are here:
RELATIONSHIP BETWEEN CHOLINESTERASE INHIBITION AND THERMOREGULATION FOLLOWING EXPOSURE TO DIISOPROPYL FLUOROPHOSPHATE IN THE RAT
Citation:
Gordon, C., L. Fogelson, J. Richards, AND J. Highfill. RELATIONSHIP BETWEEN CHOLINESTERASE INHIBITION AND THERMOREGULATION FOLLOWING EXPOSURE TO DIISOPROPYL FLUOROPHOSPHATE IN THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/109 (NTIS PB92158658).
Description:
This study examined the relationship between inhibition of cholinesterase activity (CA) and thermoregulatory response in the rat following exposure to the organophosphate (OP), diisopropyl fluorophosphate (DFP). ale Long-Evans rats were injected with DFP dissolved in peanut oil in doses ranging from 0 to 1.5 mg/kg (s.c.). Colonic (Tcol) and tail skin temperature (Ttail) were recorded at 0, 1, 2, and 3 hr post-injection. t 3 hr post-injection the rat was sacrificed and a blood sample was taken by cardiac puncture and analyzed for CA. here was a biphasic dose effect of DFP on Tcol with slight but significant elevation significant elevation in Tcol in the dose range of 0.01 to 0.5 mg/kg and a ol at doses of 1.0 and 1.5 mg/kg. here was a dose-dependent fall in CA with DFP administration in the erythrocyte, plasma, and whole blood fractions. ypothermia was associated with 80 to 87 inhibition in CA, whereas the elevation in Tcol was associated with 20 to 7-inhibition in CA. FP also elicited significant elevations in Ttail. verall, the data fail to demonstrate any clear relationship between inhibition of blood CA and thermoregulatory response following exposure to DFP. However, the elevation in Tcol following relatively low doses of DFP may be of relevance to the frequently reported symptom of fever in humans exposed to OP agents.