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CHLORDIMEFORM PRODUCES PROFOUND, SELECTIVE, AND TRANSIENT CHANGES IN VISUAL EVOKED POTENTIALS OF HOODED RATS
Citation:
Boyes, W. AND R. Dyer. CHLORDIMEFORM PRODUCES PROFOUND, SELECTIVE, AND TRANSIENT CHANGES IN VISUAL EVOKED POTENTIALS OF HOODED RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/258 (NTIS PB85192961).
Description:
Rat visual function was tested after acute exposure to chlordimeform (CDM), a formamidine insecticide/acaricide. Adult male Long-Evans rats were surgically implanted with epidural recording electrodes overlying visual cortex and tested 1 week later. Pattern reversal-evoked potentials (PREPs), flash-evoked potentials (FEPs), and FEP recovery ratios were measured after acute CDM administration. In the first study, which examined dose-response relationships, i.p. injections of 0 (saline), 5, 15, or 40 mg/kg CDM-HCl were administered 30 min prior to testing. In the second study, which examined the time course of CDM action, PREPs and paired-pulse FEPs were recorded 3, 6, and 24 h after dosage with either 0 or 40 mg/kg CDM. In summary, acute exposure to CDM temporarily increased both the amplitude and latency of PREPs, but only the latency of FEPs.