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COMPARISON OF CHLORDIMEFORM AND CARBARYL USING A FUNCTIONAL OBSERVATIONAL BATTERY (JOURNAL VERSION)
Citation:
Moser, V., J. McCormick, J. Creason, AND R. MacPhail. COMPARISON OF CHLORDIMEFORM AND CARBARYL USING A FUNCTIONAL OBSERVATIONAL BATTERY (JOURNAL VERSION). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-88/155 (NTIS PB89110514).
Description:
The effects of the formamidine pesticide chlordimeform (CDM), and the carbamate carbaryl (CAR) were compared using a functional observational battery (FOB). The FOB, a series of observations and measurements that can be rapidly administered to toxicant-treated rats, includes home-cage and open-field observations, neuromuscular and sensorimotor tests, and physiological measures. Evaluations were made according to U.S. Environmental Protection Agency testing guidelines so as to determine dose-, time-, and sex-related toxicant effects on Long-Evans hooded rats of both sexes. Both compounds affected general activity (home-cage and open-field), equilibrium, CNS excitability, and sensory responsiveness. Whereas similar decreases were obtained on rearing, gait, and arousal, there were important qualitative differences in the effects of CAR and CDM on reactions to handling and the reflex tests. Thus, the profiles of effect produced by these two pesticides could be clearly differentiated using the FOB. (Copyright (c) 1988 Society of Toxicology.)