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EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME AMINOAZOBENZENE DYES AND THEIR REDUCTIVE-CLEAVAGE PRODUCTS
Citation:
Esancy, J., H. Freeman, AND L. Claxton. EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME AMINOAZOBENZENE DYES AND THEIR REDUCTIVE-CLEAVAGE PRODUCTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/014.
Description:
Fifteen aminoazobenzene dyes and seven of their reductive-cleavage products were examined in the Salmonella/microsome assay with strains TA98, TA100, TA1535, TA1537 and TA1S38. yes tested included five derivatives of 4-aminoazobenzene with different alkoxy substituents (-0CH3, -0CH2CH3, OCH2CH2CH3, OCH2CH2CH2CH3 or -0CH2CH2OH) in the 3-position as well as the corresponding derivatives of 4-[(4-aminophenyl)azo]N,N-diethylaniline and 4-[(4-aminophenyl)azo]N,N-bis(2-hydroxyethyl)aniline. n general, as the size of the substituent ortho to the primary amino group of the dyes was increased, the mutagenicity decreased. imilar trend was observed for the reductive-cleavage products. he results from the latter aspect of this study suggest that the mutagenicity of aminoazobenzene dyes can not be accounted for solely from the properties of their reductive-cleavage products.