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SYNTHESIS OF A NOVEL FLUORINATED BENZO(A)PYRENE: 4,5-DIFLUOROBENZO(A)PYRENE
Citation:
Agarwal, S., G. Lambert, W. Padgett, AND S. Nesnow. SYNTHESIS OF A NOVEL FLUORINATED BENZO(A)PYRENE: 4,5-DIFLUOROBENZO(A)PYRENE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/246.
Description:
The synthesis of difluorobenzo(a)pyrene, as a fluorinated probe to investigate the involvement of the K-region in the further metabolic activation of benzo(a)pyrene metabolites is described. enzo(a)pyrene-,5-dione obtained from 3-dichloro-5,6-dicyano-1,4-benzoquinone oxidation of cis-4,5-dihydro-4,5-dihydroxybenzo(a)pyrene was fluorinated with dimethylaminosulfur trifluoride to give 4H,5H,4,4,5,5-tetrafluorobenzo(a)pyrene. efluorination using lithium aluminum hydride in tetrahydrofuran gave 4,5-difluorobenzo(a)pyrene.
Record Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:05/24/2002
Record Last Revised:04/16/2004
Record ID:
39118