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QUANTITATIVE GENETIC ACTIVITY GRAPHICAL PROFILES FOR USE IN CHEMICAL EVALUATION
Citation:
Waters, M., H. Stack, N. Garrett, AND M. Jackson. QUANTITATIVE GENETIC ACTIVITY GRAPHICAL PROFILES FOR USE IN CHEMICAL EVALUATION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-91/135 (NTIS PB91219139).
Description:
A graphic approach termed a Genetic Activity Profile (GAP) has been developed to display a matrix of data on the genetic and related effects of selected chemical agents. he profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical. ither the lowest effective dose (LED) or highest ineffective dose (HID) is recorded for each agent and bioassay. p to 200 different test systems are represented across the GAP. ioassay systems are organized according to the phylogeny of the test organisms and the endpoints of genetic activity. he methodology for the production and evaluation of genetic activity profiles has been developed in collaboration with the International Agency for Research on Cancer (IRAC). ata on individual chemicals has been compiled by IAC and by the U.S. Environmental Protection Agency (EPA). ata are available on 299 compounds selected from volumes 1-50 of the IAC Monographs and on 115 compounds identified as Superfund Priority Substances. oftware to display the GAPs on an IBM compatible personal computer is available from the authors. Structurally similar compounds frequently display qualitatively and quantitatively similar profiles of genetic activity. hrough the examination of the patterns of GAPs of pairs and groups of chemicals, it is possible to make more informed decisions regarding the selection of test batteries to be used in the evaluation of chemical analogs. APs have provided useful data for the development of weight-of-evidence hazard ranking schemes. lso, some knowledge of the potential genetic activity of a complex environmental mixtures may be gained from an assessment of the genetic activity profiles of component chemicals. he fundamental techniques and computer programs devised for the GAP Data Base may be used to develop similar data bases in other disciplines.