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MURINE CYTOMEGALOVIRUS HOST RESISTANCE MODELS
Citation:
Selgrade, M. AND M. Daniels. MURINE CYTOMEGALOVIRUS HOST RESISTANCE MODELS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/A-92/165 (NTIS PB92217025).
Description:
Mouse cytomegalovirus (MCMV) is a well developed and extremely useful and relevant host resistance model for immunotoxicity testing. at cytomegalovirus (RCMV) is currently under development and may have similar applications. ytomegaloviruses are species specific; RCMV is a distinct virus from MCMV and both are distinct from human cytomegalovirus (HCMV). owever, biologic and biophysical similarities between these viruses make the animal viruses good models for the human infection. his chapter discusses the rationale for using MCMV as a host resistance model, provides some representative data, and gives detailed information on methods needed to apply this model. ackground on RCMV is also presented along with detailed methods (to the extent available) for applying the RCMV model are also provided.