You are here:
SYNAPTONEMAL COMPLEX ANALYSIS IN GENETIC TOXICOLOGY
Citation:
Backer, L., M. Moses, AND J.W. Allen. SYNAPTONEMAL COMPLEX ANALYSIS IN GENETIC TOXICOLOGY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-89/155 (NTIS PB90119249).
Description:
Synaptonemal complex analysis provides a unique means of visualizing the behavior of meiotic chromosomes. he technique has been applied to the study of normal karyotypes and mutant stocks of mice. ecent work demonstrating the usefulness of SC analysis for the detection of chromosome damage suggests its potential application in a variety of mechanistic and applied studies. e have recently conducted studies to investigate cell-stage specific damage induced by radiation and expressed as SC and/or metaphase chromosome aberrations: Radiation Has found to exhibit a similar stage-specific clastogenic activity for SCs as it does for meiotic metaphase chromosomes. he nature of the chromosome damage detected depended upon the cell stage exposed and on the endpoint harvested for analysis.
