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GLUTATHIONE PEROXIDASE AND GLUTATHIONE TRANSFERASE ACTIVITY IN RAT LUNG AND LIVER FOLLOWING CADMIUM INHALATION
Citation:
Grose, E., J. Richards, R. Jaskot, M. Menache, AND J. Graham. GLUTATHIONE PEROXIDASE AND GLUTATHIONE TRANSFERASE ACTIVITY IN RAT LUNG AND LIVER FOLLOWING CADMIUM INHALATION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/088 (NTIS PB88125539).
Description:
A 2 hr inhalation exposure to 4.6 mg Cd/cu m decreased pulmonary total glutathione peroxidase (GSH Px) activity and non-selenium peroxidase (GSH non-Se-Px) activity but had no effect on GSH selenium peroxidase (Se-Px) activity. Seventy-two hrs after exposure there was an increase in total GSH Px and GSH Se-Px activity. Exposure to 0.44 mg Cd/cu m for 2 hr caused no effect on GSH Se-Px at either 0 or 72 hr post exposure, but total GSH Px and GSH non-Se-Px activities were decreased up to 72 hr post exposure. Exposure to 4.6 mg Cd/cu m caused an increase in hepatic GSH Se-Px activity 72 hr post exposure, but no other significant changes were observed in the liver. Changes in GSH non-Se-Px activity did not relate to changes in GSH transferase (Tr) activity. The data suggest that alterations in GSH Px activity by Cd(+2) may be due to changes in GSH non-Se-Px activity and that changes in pulmonary GSH Tr and GSH non-Se-Px activities may not be as closely linked as in the liver. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)