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NEUROTOXICITY OF PARATHION-INDUCED ACETYLCHOLINESTERASE INHIBITION IN NEONATAL RATS
Citation:
Veronesi, B. AND C. Pope. NEUROTOXICITY OF PARATHION-INDUCED ACETYLCHOLINESTERASE INHIBITION IN NEONATAL RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/429 (NTIS PB91171843).
Description:
The biochemical and morphological neurotoxic effects of postnatal acetylcholinesterase (AChE) inhibition were examined in rat pups dosed with parathion, at time points critical to hippocampal neurogenesis and synaptogenesis (i.e., D5-20). ippocampal cytopathology as assessed by light and electron microscopy consisted of cellular disruption and necrosis in the DG, CA4, and A3a regions. ynaptic disruption in the molecular layer was suggested by histochemical preparation using both the Timm's and AChE stains. n parathion-treated D12 pups, hippocampal AChE was depressed 7O% and QNB binding depressed by 20%. he above results indicated that definite neurotoxic consequences are associated with persistent AChE depression in the neonatal rat.