You are here:
NUCLEAR AND AXONAL LOCALIZATION OF CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE GR IN RAT CEREBELLAR CORTEX
Citation:
Jensen, K., C. Ohmstede, R. Fisher, AND N. Sayhoun. NUCLEAR AND AXONAL LOCALIZATION OF CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE GR IN RAT CEREBELLAR CORTEX. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/132 (NTIS PB91213637).
Description:
The granule cell enriched Ca2+/calmodulin dependent protein kinase (Cam kinase-Gr) may serve as a calcium activated switch involved in neuronal communication. o investigate its potential sites of action we have characterized its subcellular distribution within the cerebellum by immunochemistry and electron microscopy. nzyme mmunoreactivity is prominent in the nuclei of granule cells where it is preferentially associated with regions of dispersed chromatin. am kinase-Gr is also evident in the axons of granule cells and present to a lesser extent in the cytoplasm and dendrites of these neurons. Based on its subcellular distribution, Cam kinase-Gr provides particular neuronal populations with a coordinated CA2+-signalling pathway which may regulate several aspects of neuronal function.