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EFFECTS OF 7,12-DIMETHYLBENZ[A]ANTHRACENE ON IMMUNE FUNCTION AND MIXED-FUNCTION OXYGENASE ACTIVITY IN THE EUROPEAN STARLING
Citation:
Trust, K., A. Fairbrother, AND M. Hooper. EFFECTS OF 7,12-DIMETHYLBENZ[A]ANTHRACENE ON IMMUNE FUNCTION AND MIXED-FUNCTION OXYGENASE ACTIVITY IN THE EUROPEAN STARLING. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/302 (NTIS PB94190568).
Description:
Immune function and hepatic mixed-function oxygenase (MFO) activity were xamined in adult and nestling starlings administered a synthetic PAH, 7,12dimethylbenz[a]anthracene (DMBA). ethods used to examine the starling immune system included immunopathology, macrophage phagocytosis, lymphocyte blastogenesis to concanavalin A, and hemagglutination of sheep erythrocytes (SRBC). oncomitant investigations of MFO activity were conducted in starlings exposed to DMBA. thoxyresorufin O-dealkylase (EROD) and pentoxyresorufin O-depentylase (PROD) were used as indicators of hepatic MFO activity. hanges in MFO activity were compared to chemically altered immune responses following DMBA exposure. ubcutaneous exposure of adult starlings to 125 mg/kg DMBA resulted in suppression of lymphocyte blastogenesis and antibody production to SRBC. ROD and PROD activity was increased 2.8- and 3.4-fold, respectively. ymphocyte blastogenesis was impaired in adult starlings orally exposed to 125 mg/kg DMBA. he immune system of nestling starlings exposed orally to 100 mg/kg DMBA was altered, as evidenced by decreased phagocytic ability of macrophages and inhibition of lymphocyte blastogenesis. ral exposure to DMBA did not induce MFO activity in starlings of either age class. ffects of DMBA on immune function and MFO activity in starlings varied with the age of birds and route and length of chemical exposure.
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EFFECTS OF 7,12-DIMETHYLBENZ[A]ANTHRACENE ON IMMUNE FUNCTION AND MIXED-FUNCTION OXYGENASE ACTIVITY IN THE EUROPEAN STARLING