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AUDITORY DEFICITS AND MOTOR DYSFUNCTION FOLLOWING IMINODIPROPIONITRILE ADMINISTRATION IN THE RAT
Citation:
Crofton, K. AND T. Knight. AUDITORY DEFICITS AND MOTOR DYSFUNCTION FOLLOWING IMINODIPROPIONITRILE ADMINISTRATION IN THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/017 (NTIS PB92143890).
Description:
The behavioral effects of 3,3'-iminodipropionitrile (IDPN) were studied using reflex modification of the acoustic startle response and figure-eight maze activity. umber of experiments were conducted with separate groups of adult male Long Evans hooded rats exposed to saline, or 50 - 500 mg/kg IDPN for 3 consecutive days. Auditory thresholds (reflex modification), motor activity, and grip strength were measured 1 day, and 1, 3, and 9 weeks post-dosing. eflex inhibition was monitored daily, prior to, during and for 7 days following exposure. uditory thresholds for 5- and 40-kHz tones were elevated approximately 25 dB and 50 dB, respectively. he onset of this auditory dysfunction in the 200 mg/kg/day group, as demonstrated by a loss of reflex inhibition, was 2 days for the 40-kHz tone and 4 days for the 5-kHz tone. otor activity was increased up to 400% in the 200 mg/kg group, whereas there was no alteration in hindlimb grip strength. hese data demonstrate dosage- and time-dependent alterations in auditory and motor function following IDPN exposure.