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ALLYLISOPROPYLACETAMIDE INDUCES RAT HEPATIC ORNITHINE DECARBOXYLASE
Citation:
Kitchin, K. AND J. Brown. ALLYLISOPROPYLACETAMIDE INDUCES RAT HEPATIC ORNITHINE DECARBOXYLASE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/533.
Description:
In rat liver, allylisopropylacetamide (AIA) treatment strongly induced (25-fold) the activity of rat hepatic ornithine decarboxylase (ODC). y either the oral or the subcutaneous routes, AIA produced a long-lasting induction (30 to 4O hours) of hepatic ODC activity. hree analogs of AIA propylisopropylacetamide (PLA), allobarbital, and allybenzene, were active ODC inducers while a fourth , allylacetate, was not. lthough induction of hepatic aminolevulinic acid (AIA) synthetase activity and the accumulation of hepatic prophyrins depend on the ally moiety of AIA, this is not the case with hepatic ODC induction. llylisopropylacetamide did not elevate serum alanine aminotransferase (SGPT) not did it cause DNA damage, as measured by the alanine alkaline elution assay. hus, hepatic cell death is not a likely explanation of AlA'S long-lasting induction of ODC. s AIA does not belong to any of the common categories of ODC inducers, it may be the chemical prototype of a new class hepatic ODC inducers.