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EFFECT OF AMBIENT TEMPERATURE AND RUNNING WHEEL ACTIVITY ON THE OUTCOME OF PREGNANCY IN CD-1 MICE
Citation:
Berman, E., D. House, AND H. Carter. EFFECT OF AMBIENT TEMPERATURE AND RUNNING WHEEL ACTIVITY ON THE OUTCOME OF PREGNANCY IN CD-1 MICE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/125 (NTIS PB91109645).
Description:
The effect of ambient temperature (Ta) and running wheel activity (RWA) on fetal outcome was studied in CD-1 mice. regnant mice were allowed to be active in a running wheel at various Ta's (26, 30, 32, 34 or 36C) for 100 mins a day. he dams were killed near term, and various maternal and fetal measurements made. ean deep body temperature (Tb) in pregnant dams while runnIng (measured using radio-teletherflometers implanted in the abdomen) was raised to 39.5 C at Ta=36. red mice continued to increase their RWA, pregnant or not, but pregnant mice exercise less from mid-pregnancy on. WA up to 1 km/hr had no effect on maternal weight gain, litter size, number of live fetuses, fetal body weight and fetal relative brain weight. owever, increasing Ta was effective in decreasing maternal weight gain and fetal body weight, and increasing fetal relative brain weight. ven though Tb can be increased significantly by either RWA or Ta' the increase caused by RWA appears to have no significant influence on the outcome of pregnancy. t levels in this study Tb per se does not appear to be the variable on which to predict fetal effects. his is because only Tb from Ta, and not Tb from RWA, could be shown to effect a fetal change.