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GENOTOXICITY OF THREE PYRIDINE COMPOUNDS TO L5178Y MOUSE LYMPHOMA CELLS
Citation:
Dearfield, K.L., K. Harrington-Brock, C.L. Doerr, L. Parker, AND M. Moore. GENOTOXICITY OF THREE PYRIDINE COMPOUNDS TO L5178Y MOUSE LYMPHOMA CELLS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/020 (NTIS PB93156255).
Description:
The L5l78Y mouse lymphoma assay was used to examine the potential mutagenicity of three halogenated pyridine compounds. Position effects of the halogen moiety and role of metabolic activation were analyzed based on induced mutant frequency, gross aberrations, and micronuclei. ithout activation, 2-chloropyridin, 3-chloropyridin, and 2-chloro-5-trifluoromethylpyridine produced a small increase in mutant frequency; only the 2-chloropyridine activity was significantly increased with metabolic activation. ll three compounds were also clastogenic as increased in aberrations and micronuclei were induced (except for 2-chloro-5-trifluoromethyl-pyridine which did not induce micronuclei either with or without activation).