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PHOSPHINE-MEDIATED HEINZ BODY FORMATION AND HEMOGLOBIN OXIDATION IN HUMAN ERYTHROCYTES
Citation:
Potter, W., S. Rong, J. Griffith, J. White, AND V. Garry. PHOSPHINE-MEDIATED HEINZ BODY FORMATION AND HEMOGLOBIN OXIDATION IN HUMAN ERYTHROCYTES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/201.
Description:
Exposure of hen erythrocytes in vitro to phosphine (PH 3) induces the development of Heinz body lesions. he lower limit for phosphine mediated Heinz body formation is 1.25 ppm for a four hour exposure. t exposure levels of 3.0 ppm or higher all erythrocytes are observed to contain Heinz body lesions. hese higher phosphine concentration levels have been observed to occur within certain occupational settings. he mechanism of phosphine mediated Heinz body formation depends upon an oxygen dependent hemoglobin oxidation with initial metHb formation before subsequent protein precipitation and hemochrome formation.