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NINETY-DAY SUBCHRONIC STUDY OF THE TOXIC EFFECTS OF DICHLOROACETATE IN DOGS
Citation:
Cicmanec, J., L. Condie, G. Olson, AND S. Wang. NINETY-DAY SUBCHRONIC STUDY OF THE TOXIC EFFECTS OF DICHLOROACETATE IN DOGS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/071 (NTIS PB92150853).
Description:
Male and female juvenile Beagle dogs were dosed daily for 90 days with dichloroacetate. he compound was administered orally via gelatin capsule at doses of 0, 12.5, 39.5 and 72 mg/kg/day. ach dose group consisted of 5 males and 5 females. he dogs were observed clinically and blood samples were taken at 15 day intervals for hematologic and serum chemistry values. Decreased total erythrocyte count and hemoglobin levels were observed in mid and high dose dogs beginning at day 30. erum concentrations of LDH were elevated at days 30 and 45 in females and at day 75 in males treated with at 72 mg/kg/day. ne female of the high dose group died at day 50 and two high dose males died at days 51 and 74. ind limb partial paralysis was observed in many high dose dogs. acuolization of myelinated white tracts of cerebrum, cerebellum, and/or spinal cord was observed in many high dose dogs as well as some mid and low dose subjects. egeneration of testicular germinal epithelium and syncytial giant cell formation was noted in males of all dose groups. epatic vacuolar change and chronic hepatitis appeared only in DCA-treated dogs. n addition, suppurative bronchopneumonia and chronic pancreatitis was noted in many high dose and some mid dose subjects. no effect level" was not determined in this study.