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TOXICOLOGY OF ORGANIC DRINKING WATER CONTAMINANTS: TRICHLOROMETHANE, BROMODICHLOROMETHANE, DIBROMOCHLOROMETHANE AND TRIBROMOMETHANE
Citation:
Munson, A., L. Sain, V. Sanders, B. Kauffmann, AND K. White. TOXICOLOGY OF ORGANIC DRINKING WATER CONTAMINANTS: TRICHLOROMETHANE, BROMODICHLOROMETHANE, DIBROMOCHLOROMETHANE AND TRIBROMOMETHANE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/369.
Description:
This study evaluated the subchronic toxicity of selected halomethanes which are drinking water contaminants. The compounds studied were trichloromethane, bromodichloromethane, dibromochloromethane and tribromomethane. Subchronic 14-day gavage studies were performed with the use of doses encompassing one-tenth the LD50 for the compounds. A 90-day gavage study of one of the compounds, trichloromethane, was also done. Parameters observed included body and organ weights, histopathology, hematology, clinical chemistries, and hepatic microsomal enzyme activities.