You are here:
IMPAIRMENT OF CALCIUM HOMEOSTASIS BY HEXACHLOROBENZENE (HCB) EXPOSURE IN FISCHER 344 RATS (JOURNAL VERSION)
Citation:
Andrews, J., K. Courtney, AND W. Donaldson. IMPAIRMENT OF CALCIUM HOMEOSTASIS BY HEXACHLOROBENZENE (HCB) EXPOSURE IN FISCHER 344 RATS (JOURNAL VERSION). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-88/061 (NTIS PB89110332).
Description:
Human exposure to hexachlorobenzene (HCB) has resulted in demineralization of bone with osteoporosis resulting. Experiments were undertaken to investigate the effects of HCB on the homeostatic mechanism of calcium metabolism. Fischer 344 rats were dosed with 0, 0.1, 1.0, 10.0 or 25.0 mg HCB/kg body weight 5 days/wk for 5 wks while being fed normal rat diet or vitamin D3 deficient diet. Rats receiving the normal diet had a dose-related decrease in body weight gain and increased liver weight when compared to their controls. Serum cholesterol, alanine aminotransferase (ALT), 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D) and parathyroid hormone (PTH) were significantly elevated when compared to control values. In the vitamin D3 deficient diet group, there was a dose related increase in liver weight, liver-to-body-weight ratio and kidney-to-body-weight ratio. Serum cholesterol and 1,25-(OH)2D were significantly elevated. The data indicate that HCB does affect calcium metabolism by altering the concentrations of two primary controlling factors in calcium homeostasis. (Copyright (c) 1988 by Hemisphere Publishing Corporation.)