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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF O-TOLUIDINE HYDROCHLORIDE
Citation:
EVALUATION OF THE POTENTIAL CARCINOGENICITY OF O-TOLUIDINE HYDROCHLORIDE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-91/189.
Description:
o-Toluidine hydrochloride is a potential human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carcinogenicity from animal studies is "Sufficient," and the evidence from human studies is "Inadequate." he potency factor (F) for o-toluidine hydrochloride is estimated to be 0.069 (mg/kg/day)-1 placing R in, potency group 3 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, o-toluidine hydrochloride is assigned a "LOW" hazard ranking for the purposes of RQ adjustment.