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NEW APPROACHES TO QUANTITATING THE PULMONARY EFFECTS OF INHALED POLLUTANTS
Citation:
Bromberg, Philip A., R. Boucher, M. Friedman, M. Hazucha, AND R. Pimmell. NEW APPROACHES TO QUANTITATING THE PULMONARY EFFECTS OF INHALED POLLUTANTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-81/052 (NTIS PB81222382).
Description:
The authors have developed a variety of non-invasive and other techniques to study effects of inhaled pollutants on the lung. In the area of airway mechanics they have developed and applied a diameter gauge to make continuous measurements of large airways caliber. The gauge provides an electric output. The authors have also developed and validated rapid methods for non-invasively measuring respiratory mechanics using forced random noise excitation at the mouth. The resulting respiratory impedance data are applied to appropriate models to obtain values for parameters such as 'central' and 'peripheral' airways resistance. In the area of repiratory epithelial function they have developed a nontraumatic technique to measure transepithelial potential difference across respiratory (nasal and airways) epithelium. The authors have also measured tracheal epithelial permeability in vivo, demonstrating increased permeability and decreased permselectivity in guinea pigs exposed to 4 ppm, 1 ppm and 0.3 ppm O3. In the area of pulmonary vasculature, they have developed a rapid noninvasive multi-gas rebreathing technique to measure lung water and used it to develop an O3 - induced pulmonary caine model of delayed pulmonary edema using 1 ppm O3.