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ACUTE, 14-DAY REPEATED DOSING, AND 90-DAY SUBCHRONIC TOXICITY STUDIES OF POTASSIUM PICLORAM (JOURNAL VERSION)
Citation:
Hayes, J., L. Condie, AND J. Borzelleca. ACUTE, 14-DAY REPEATED DOSING, AND 90-DAY SUBCHRONIC TOXICITY STUDIES OF POTASSIUM PICLORAM (JOURNAL VERSION). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-86/473.
Description:
Potassium picloram was administered either by gavage (acute studies) or in drinking water to male and female Sprague-Dawley derived rats (14-day and 90-day studies). The acute oral LD50 was 950 mg/kg (812-1120) for males and 686 mg/kg (599-786) for females. Depression, prostration, ataxia, tremors and convulsions preceded death. There were no consistent biologically significant compound related effects in rats that received 60, 190 or 600 mg potassium picloram/kg/day for 14 days. In the subchronic study, rats received 60, 190, 600 or 1070 mg potassium picloram/kg/day for 90 consecutive days. There were only 4 male and 2 female survivors out of 20 rats of each sex at the 1070 mg/kg dose and 16 male and 18 female survivors at the 570 mg/kg dose. Mortality was dose-dependent. No specific organ site toxicity could be identified in these studies. Toxicity from exposure to picloram in drinking water is apparently low. (Copyright (c) 1986 by the Society of Toxicology.)