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RELATIONSHIP BETWEEN DELIVERED OZONE DOSE AND FUNCTIONAL RESPONSES IN HUMANS
Citation:
Gerrity, T., W. McDonnell, AND D. House. RELATIONSHIP BETWEEN DELIVERED OZONE DOSE AND FUNCTIONAL RESPONSES IN HUMANS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/336 (NTIS PB94202082).
Description:
The relationship between delivered ozone dose and variability of pulmonary function response to ozone was investigated in 20 young, healthy non-smoking male volunteers. he subjects were exposed to 0.4 ppm ozone for one hour during which they walked on a treadmill at a speed and inclination sufficient to induce a minute ventilation (VE) of 20 L/min/m2 body surface area. rior to, and immediately following exposure spirometric and plethysmographic measurements of lung function were made. n addition, 5 minutes after the beginning of exposure and 5 minutes before the end of exposure the uptake efficiency of ozone in the upper and lower respiratory tract, spontaneous tidal volume (Vt), and breathing frequency (f) were measured. ptake efficiencies in the upper (F URT) respiratory tracts were determined by continuously drawing air from the posterior pharynx into a rapidly responding chemiluminescent ozone analyzer. inear regression models were constructed to examine the relationships between pulmonary function and breathing pattern responses, and the instantaneous and average values of F LRT and V E. he results suggest that delivered dose, as determined primarily by V E; is responsible for some of the intersubject variability of ozone response. he failure of LRT to play a significant role may be due to the fact that it primarily reflects ozone uptake in the lung periphery distal to anatomical sites where the ozone response may be mediated.