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COLLECTION, CHEMICAL FRACTIONATION, AND MUTAGENICITY BIOASSAY OF AMBIENT AIR PARTICULATE
Citation:
Huisingh, J., M. Waters, L. Claxton, A. Kolber, AND T. Wolff. COLLECTION, CHEMICAL FRACTIONATION, AND MUTAGENICITY BIOASSAY OF AMBIENT AIR PARTICULATE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-81/286 (NTIS PB83239731).
Description:
The influence of industrialization and consequent increased concentration of urban particulate matter on the incidence of cancer has long been a concern. The first bioassays used to evaluate complex ambient air samples were whole-animal carcinogenesis bioassays. In these studies, organic extracts of urban particulate matter were found to be carcinogenic in rodents. Carcinogenic polycyclic aromatic hydrocarbons (PAH), such as benzo(a)pyrene, were detected in these extracts; however, these compounds did not account for all of the carcinogenic activity reported.