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GLUCOCORTICOIDS REGULATE THE CONCENTRATION OF GLIAL FIBRILLARY ACIDIC PROTEIN THROUGHOUT THE BRAIN
Citation:
O'Callaghan, J., R. Brinton, AND B. McEwen. GLUCOCORTICOIDS REGULATE THE CONCENTRATION OF GLIAL FIBRILLARY ACIDIC PROTEIN THROUGHOUT THE BRAIN. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/404.
Description:
The role of glucocorticoids in the in vivo regulation of glial fibrillary acidic protein was examined. orticosterone administration to adult rats resulted in decreased levels of GFAP throughout the brain whereas adrenalectomy caused levels of GFAP to increase. orticosterone administration to adrenalectomized rats lowered GFAP levels to values below those of sham controls. hus, the expression of GFAP throughout the brain appears to be physiologically regulated by adrenal glucocorticoids.
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GLUCOCORTICOIDS REGULATE THE CONCENTRATION OF GLIAL FIBRILLARY ACIDIC PROTEIN THROUGHOUT THE BRAINRecord Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:05/24/2002
Record Last Revised:04/16/2004
Record ID:
37713