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PREDICTIVE ASSAY FOR RODENT CARCINOGENICITY USING IN VIVO BIOCHEMICAL PARAMETERS: OPERATIONAL CHARACTERISTICS AND COMPLEMENTARITY
Citation:
Kitchin, K., J. Brown, AND A. Kulkarni. PREDICTIVE ASSAY FOR RODENT CARCINOGENICITY USING IN VIVO BIOCHEMICAL PARAMETERS: OPERATIONAL CHARACTERISTICS AND COMPLEMENTARITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/259 (NTIS PB92206390).
Description:
Linear models of risk assessment may be appropriate for chemicals that are initiators of carcinogenesis while threshold models of risk assessment have been proposed for promoters. he proper risk assessment model for the regulation of promoters of carcinogenesis remains an active area of research and controversy. ancer is a multistage process (e.g. initiation, promotion and progression). hese three stages of the oncogenic process have different biological characteristics. tudies to determIne which chemicals effect which stages and to what degree are needed for risk assessment. he in vivo biochemical system described in this report can be performed in a species specific and organ specific manner. n this study 11 chemicals were administered to rats, and the operational characteristics for predicting rodent carcinogenicity determined. he complementarity to short-term mutagenicity tests was also emonstrated.