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ASSESSMENT OF BORIC ACID AND BORAX USING THE IEHR EVALUATIVE PROCESS FOR ASSESSING HUMAN DEVELOPMENT AND REPRODUCTIVE TOXICITY OF AGENTS
Citation:
Moore, J. ASSESSMENT OF BORIC ACID AND BORAX USING THE IEHR EVALUATIVE PROCESS FOR ASSESSING HUMAN DEVELOPMENT AND REPRODUCTIVE TOXICITY OF AGENTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/R-96/021.
Description:
This document presents an evaluation of the reproductive and developmental effects of boric acid, H3803 (CAS Registry No. 10043-35-3) and disodium tetraborate decehydrate or borax, Na2B4O2O(CAS Registry No. 1303-96-4). he element, boron, does not exist naturally. oron always exists, in nature, in combination with oxygen, such as boric acid, or as borate salts. n dilute aqueous solution and at physiological pH (7.4), the predominant species is undissociated boric acid (greater than 98%), irrespective of whether the initial material was boric acid or borax. herefore, it is both useful and correct to compare exposures and dosages to boric acid and borax in terms of "boron equivalents", since both materials form equivalent species in dilute aqueous solution with similar systemic effects. n order to be clear in this document, the term "boron" will refer to "boron equivalents" or percent boron in boric acid and borax. lso it is likely that boron, not boric acid, would be measured in water supplies, food etc., making boron equivalents much more useful for regulatory agencies.